ECT Generates a Postictal Wave of Spreading Depolarization in Mice and Humans
Out on PubMed, from authors in the USA, is this paper: Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans. Rosenthal ZP, Majeski JB, Somarowthu A, Quinn DK, Lindquist BE, Putt ME, Karaj A, Favilla CG, Baker WB, Hosseini G, Rodriguez JP, Cristancho MA, Sheline YI, William Shuttleworth C, Abbott CC , Yodh AG, Goldberg EM. Nat Commun. 2025 May 18;16(1):4619. doi: 10.1038/s41467-025-59900-1. PMID: 40383825 The abstract is copied below: Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the underlying neurobiology is understudied and unresolved. Using optical neuroimaging of neural activity and hemodynamics in a mouse model of ECT, we demonstrated that a second brain event follows seizure: cortical spreading depolarization (CSD). We found th...