ECT and Treatment Resistance: New Study in Acta Psychiatrica Scandinavica
The impact of treatment resistance on outcome and course of electroconvulsive therapy in major depressive disorder. Rovers JJE, Vissers P, Loef D, van Waarde JA, Verdijk JPAJ, Broekman BFP, Vergouwen ACM, Oudega ML, van Exel E, Coenen R, Everaerd DS, Tendolkar I, Dols A, van Eijndhoven PFP. Acta Psychiatr Scand. 2023 Mar 30. doi: 10.1111/acps.13550. Online ahead of print. PMID: 3702042 The abstract is copied below: Introduction: Major depressive disorder (MDD) is a common psychiatric disorder. Despite several treatment options, a subgroup of patients will not respond to the commonly used antidepressant treatments and thus express treatment resistance (TRD). TRD can be quantified with the Dutch Measure for Treatment Resistance in Depression (DM-TRD). Electroconvulsive therapy (ECT) is an effective treatment for MDD, also in TRD. Yet, the position of ECT as "treatment-of-last-resort" may decrease the likelihood of beneficial outcome. Our aim was to investigate the association