BDNF Isoform Required For Neuroplasticity: ECS Study From Johns Hopkins
Out on PubMed, from researchers at Johns Hopkins University School of Medicine, is this paper: Induction of Bdnf from promoter I following electroconvulsive seizures contributes to structural plasticity in neurons of the piriform cortex. Ramnauth AD, Maynard KR, Kardian AS, Phan BN, Tippani M, Rajpurohit S, Hobbs JW, Page SC, Jaffe AE, Martinowich K. Brain Stimul. 2022 Feb 17:S1935-861X(22)00031-6. doi: 10.1016/j.brs.2022.02.003. Online ahead of print. PMID: 35183789 The abstract is copied below: Background: Electroconvulsive therapy (ECT) efficacy is hypothesized to depend on induction of molecular and cellular events that trigger neuronal plasticity. Investigating how electroconvulsive seizures (ECS) impact plasticity in animal models can help inform our understanding of basic mechanisms by which ECT relieves symptoms of depression. ECS-induced plasticity is associated with differential expression of unique isoforms encoding the neurotrophin, brain-derived neurotrophic factor (B