Assessment of Seizure Duration and Utility of Using SedLine® EEG Tracing

Out on PubMed, from clinicians in Boston, is this paper:

Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis.

Amirfarzan H, Cassidy KJ, Moaddab M, Demin M, Schumann R, Lewis B.J Anesth Analg Crit Care. 2024 Feb 6;4(1):8. doi: 10.1186/s44158-024-00143-9.PMID: 38321515

The abstract is copied below:

Background: Electroconvulsive therapy (ECT) endures as a definitive treatment for refractory depression and catatonia and is also considered an effective treatment for a number of other severe psychiatric disorders (Lisanby, N Engl J Med 357:1939-1945, 2007)(Weiner and Prudic, Biol Psychiatry 73:105-106, 2013). GA is an essential component of the ECT procedure for various reasons (Lee, Jenkins and Sparkle, Life 11, 2021). Monitoring anesthetic effects on the brain is desirable as anesthetic agents affect seizure duration and recovery (Rasulo, Hopkins, Lobo, et al, Neurocrit Care 38:296-311, 2023) (Jones , Nittur , Fleming and Applegate, BMC Anesthesiol 21:105, 2021) (Soehle , Kayser , Ellerkmann and Schlaepfer, BJA 112:695-702, 2013). Perioperative anesthetic effects on consciousness can be assessed with brain function monitoring using raw electroencephalogram (EEG) traces and processed EEG indices.

Objective: We examined the usefulness and utility of the SedLine® anesthetic effect monitor during ECT procedures. We hypothesized that the seizure duration as measured by the EEG tracing of the ECT machine is equivalent to the duration assessed by the SedLine® EEG tracing. A secondary objective was to describe the SedLine® patient state indices (PSI) at different phases of treatment.

Methods: Following IRB approval, we analyzed the data of the electronic medical records of 45 ECT treatments of 23 patients in an urban VA medical center between July 01, 2021, and March 30, 2022. We compared the seizure duration in minutes and seconds as measured either by the ECT machine EEG tracing or the SedLine® EEG tracing. We then collected SedLine® processed EEG indices at four different stages during the treatment. Appropriate comparative and observational statistical analyses were applied.

Results: There was no significant difference in measured seizure duration between the two methods examined (p < 0.05). We observed a lag of the SedLine PSI value at the time before stimulus delivery and limited PSI utility during the course of ECT.

Conclusion: The SedLine® EEG tracing can be an alternative to the machine EEG tracing for the determination of seizure duration. The SedLine® processed EEG indices are not consistently useful before and after ECT delivery. Anesthetic effect monitoring during ECT is feasible.

Keywords: Anesthetic IV; Depth of anesthesia; Electroconvulsive therapy; Methohexital; Processed EEG; SedLine®.

The article is here.

And from the text:

This starts out like an advertisement for the Sedline anesthetic effect monitor, but then it goes off the rails. It shows that the device is of little utility in ECT. Better to just monitor motor seizure by the cuff method, EEG seizure by the EEG on the ECT device. Oh, and monitor anesthesia effect by talking to the patient...

But the figure is colorful and artistic!