Well, today's post is about basic science, not clinical, but translatable and interesting. This article is new on PubMed today:
Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation
von Wittgenstein J, et al. Cereb Cortex 2020. PMID 32080705
Here is the url for the Pdf:
https://drive.google.com/file/d/1DeZCm_DKJyZjfGddNGv3ofoStJyMY7k4/view?usp=sharing
This is a very complex animal study, the main finding of which is that ECS (the animal analog of ECT in humans) induced the transcription factor Sox11 selectively in the dentate gyrus of mice, and not in other hippocampal subfields. Such information adds to the understanding of neuronal plasticity and dovetails interestingly with the recently discussed neuroimaging work of the UCLA group showing ECT-induced structural changes only in certain hippocampal regions (Hippocampal subregions and networks linked with antidepressant response to electroconvulsive therapy.)
Many investigators around the world are making progress in elucidating the mechanism of action of ECT...
https://drive.google.com/file/d/1DeZCm_DKJyZjfGddNGv3ofoStJyMY7k4/view?usp=sharing
This is a very complex animal study, the main finding of which is that ECS (the animal analog of ECT in humans) induced the transcription factor Sox11 selectively in the dentate gyrus of mice, and not in other hippocampal subfields. Such information adds to the understanding of neuronal plasticity and dovetails interestingly with the recently discussed neuroimaging work of the UCLA group showing ECT-induced structural changes only in certain hippocampal regions (Hippocampal subregions and networks linked with antidepressant response to electroconvulsive therapy.)
Many investigators around the world are making progress in elucidating the mechanism of action of ECT...
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