Case Report- ECT-responsive Mania in Velocardiofacial Syndrome

Out on PubMed, from clinicians at Penn State University College of Medicine, is this case report:Recurrent Mania in an Adolescent with Velocardiofacial Syndrome and Treatment Challenges.

Hasoglu T, Waxmonsky JG, Baweja R.Bipolar Disord. 2020 Sep 22. doi: 10.1111/bdi.12992. Online ahead of print.PMID: 32960492
The abstract is copied below:
Patients with Velocardiofacial syndrome can present with recurrent mania in adolescence, and may have poor response and tolerability with conventional treatments. Complex and variable clinical manifestation and comorbidities can complicate the management and require multidisciplinary approach. Clinicians should consider ECT in the early stages of treatment along with mood stabilizers.
This is a well-presented case report that deserves to be read in its entirety. 
It describes a 16 y.o. male with Velocardiofacial Syndrome (DiGeorge Syndrome) and autism spectrum disorder who developed classic mania that was either quickly recurrent, or not initially fully treated.
When treated with risperidone and intramuscular haloperidol, he developed catatonia, although the authors do not link the catatonia to this treatment.
ECT was rapidly effective for the mania, with response apparent even after the first treatment.
The authors reveal a strong family history of bipolar disorder later in the report. Despite this, they conceptualize the patient's mania as a likely comorbidity with his genetic syndrome; I think it may just be the common mood disorder (bipolar) that runs in the family, presenting in a family member with a rare genetic syndrome.

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