ECT For Parkinson's Disease: New Study From Iran

 Out on PubMed, from investigators in Iran, is this study:

Efficacy of electroconvulsive therapy in Parkinson's disease: a clinical trial.

Afshari D, Shakeri J, Khodamoradi M, Nejad Shahrokh Abadi R, Rahkan J, Afshar Hezarkhani L.Neurosci Lett. 2022 Jan 10:136449. doi: 10.1016/j.neulet.2022.136449. Online ahead of print.PMID: 35026333
The abstract is copied below:

Motor and psychiatric symptoms in patients with Parkinson's disease (PD) constitute some of the most problematic issues for both the patients and their caregivers. This study evaluated the short- and long-term efficacy of electroconvulsive therapy (ECT) in PD patients whose psychiatric symptoms had been exacerbated due to drug therapy. Fifteen PD patients were treated using an electroshock device at a range of 25-100 Joules over a period of 6 weeks, during 12 sessions. Motor and psychiatric symptoms of all patients were evaluated before conducting ECT as baseline, after 12 sessions of ECT at the 6th week, and one month after completion of the treatment at the 10th week. The results showed that the variables mentation, behavior, mood, performance of daily activities, and severity of motor and psychiatric symptoms, were significantly improved at the end of the 6th and 10th weeks when compared with the baseline. Moreover, the results revealed that the mean values were significantly different only for motor symptoms at the end of the study (10th week) compared with the second time point. The current trial may indicate that ECT could potentially serve as a viable treatment for PD patients with refractory psychiatric symptoms. However, due to waning efficacy of ECT, it is recommended that PD patients undergo a conventional treatment in conjunction with periodic ECT sessions to ensure an optimal medical outcome.

Keywords: Electroshock therapy; Parkinson’s disease; drug therapy; motor symptoms; psychiatric symptoms.

The article is here.


And from the text:

I particularly like the below highlighted sentence:

This is small (n=15) study of acute bilateral ECT in patients with drug-refractory Parkinson's Disease (PD). The findings of improvement in both motor and psychiatric symptoms are consistent with the prior literature. The observation that in order to maintain benefits, acute treatment needs to be followed up with maintenance ECT, is also well taken.
While the paper has many shortcomings, many are attributable to language difficulties and can be forgiven. And the above highlighted sentence is a novel, and perhaps, helpful, way to describe ECT.
Kudos to these authors in Iran for highlighting the efficacy of ECT in PD, something that remains overlooked and understudied in neurological circles. A full read will be ~15 minutes.

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