ECT For Limbic Encephalitis: Two Cases in JECT LTE

 Out on PubMed, in JECT, from a clinician in Philadelphia, is this LTE:

Two Cases of Limbic Encephalitis Successfully Treated With Electroconvulsive Therapy After Standard Immunomodulating Therapy Was Unsuccessful.

Schardt M.J ECT. 2022 Jul 19. doi: 10.1097/YCT.0000000000000874. Online ahead of print.PMID: 35900110
The LTE is here:

Here are two more interesting cases of limbic encephalitis, unresponsive to immunotherapy, but responsive to ECT. I conclude that ECT is an effective immunotherapy for this neurologic disease. I say that only slightly tongue-in-cheek, and of course, if there is an underlying pathology (e.g.teratoma) it must be addressed, but...there are now many such cases in the literature and they make more urgent the question of sequencing of treatments. Analogous to how many failed AD trials must a severely depressed patient be subjected to, how many failed immunotherapy trials must a LE patient be subjected to before ECT is recommended?
I know you have opinions and I hope to hear them in the "comments," thanks.


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