Role of ECT in Neuroplasticity Hypothesis of Depression: New LTE in Molecular Psychiatry

Out on PubMed, from researchers in Germany, is this LTE:

Hippocampal neuroplasticity, major depression and, not to forget: ECT.

Sartorius A, Karl S, Zilles-Wegner D.Mol Psychiatry. 2022 Aug 29. doi: 10.1038/s41380-022-01746-w. Online ahead of print.PMID: 36038727 

The letter is here.

And here:


Nicely dividing the evidence between animal and human studies, the authors make the case for the centrality of ECT in elucidating the etiopathogenesis of depression. They call out a prior publication in Molecular Psychiatry for having overlooked ECT.
Kudos to Drs. Sartorius, Karl, and Zilles-Wegner for standing up for the scientific and clinical importance of ECT. 

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