ECT and Neuroplasticity: Authors Respond to Sartorius et al. LTE

Out on PubMed, is this LTE in Molecular Psychiatry:

Electroconvulsive therapy-a shocking inducer of neuroplasticity?

Tartt AN, Mariani M, Hen R, Mann JJ, Boldrini M.Mol Psychiatry. 2023 Mar 3. doi: 10.1038/s41380-023-02015-0. Online ahead of print.PMID: 36869226

The letter is here.
And here:
This is a comprehensive response to the prior LTE from Sartorius and colleagues in which they called out the authors of the original review of neuroplasticity in antidepressant treatment for omitting ECT. So here they speculate about neuronal mechanisms underlying both the rapid and more long-term effects of ECT. Kudos to both sets of authors for recognizing the omission, and then correcting it with this thoughtful response.
One still wonders about the rare patient who has a switch from profound depression to euthymia or hypomania immediately after a single treatment...

(Please see also blog post of September 18, 2022.)

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