ECT For Patients With Clozapine-Refractory Schizophrenia: LTE in Schizophrenia Research

Out on PubMed, from authors at the Mayo Clinic, is this LTE: 

Role of electroconvulsive therapy in patients with clozapine-refractory schizophrenia.

Markota M, Croarkin PE, Gentry MT, Leung JG.Schizophr Res. 2024 May 21;269:130-131. doi: 10.1016/j.schres.2024.05.013. Online ahead of print.PMID: 38776722


The LTE is here.

And here:





This is a critique of a study published in Schizophrenia Research which concluded that ECT was ineffective in patients with clozapine-resistant schizophrenia (CRS).

The arguments in this LTE are a bit convoluted, but boil down to saying that ECT works if the CRS is severe. One would have to think this is true, given both the extant literature and vast clinical experience.

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